
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Accutane and call your doctor at once if you have any of these serious side effects:
* depressed mood
* sudden numbness or weakness
* blurred vision
* hearing problems, hearing loss, or ringing in your ears;
* severe pain in your upper stomach
* loss of appetite
* severe diarrhea
* fever, chills, body aches, flu symptoms, , easy bruising or bleeding
* joint stiffness, bone pain or fracture.

During puberty, the production of male sex hormones (androgens) increases in both girls and boys, which can stimulate the sebaceous glands to produce more sebum. In some people, the sebaceous glands are extremely sensitive to androgens. These people, mostly men, get acne so severely that they need medical treatment. The increased production of sebum makes the openings of the sebaceous glands narrower, which prevents the sebum from getting out. Meanwhile, the sebum production continues regardless.

Roaccutane is an oral drug developed by the Roche company for treatment of the most severe form of acne. Where other medications often fall short, Roaccutane is powerful enough to treat acne that can leave the patient permanently disfigured. Roaccutane capsules contain the active ingredient isotretinoin. Isotretinoin belongs to a group of medicines known as retinoids, which are derivatives of vitamin A. Isotretinoin taken by mouth works by reducing the production of the skin's natural oil

Acne is a very common skin disorder that most young people get in early puberty. It is caused by inflammation of the small oil glands (sebaceous glands) that surround the fine hairs on the face and chest. The severity of acne increases and, typically, reaches its peak around the ages of 17 to 19. For most people, acne tends to go away by the time they reach their mid-20s; however, very sensitive people may continue to have the disorder until they reach their 40s.

The first symptoms are small, tender, red spots that later turn into pimples containing degraded fatty acids. The inflammation disappears over a few days or weeks, depending on the severity. Severe acne can cause scars which will never disappear. Acne can also cause psychological stress and be socially disabling.

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Each prescription of Accutane must be filled within 7 days of the date it was prescribed by your doctor. You will receive no more than a 30-day supply of Accutane at one time. Always take Accutane with a full glass of water to prevent the capsule from melting in your esophagus (food pipe), causing irritation. Do not chew or suck on the capsule. Swallow it as quickly as possible.

Isotretinoin decreases the size and activity of the sebaceous glands in the skin, which reduces the amount of sebum that is produced. This stops the glands becoming blocked, and means bacteria are less likely to thrive. It also reduces the inflammation in the skin. Isotretinoin can have serious side effects and its use must be supervised by a dermatologist. It is reserved for the treatment of severe acne (such as nodular or conglobate acne or acne at risk of permanent scarring) that has not improved with standard treatment involving oral antibiotics and topical medicines.
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